1.1 ,This procedure details the determination of thiodiglycol (TDG), also known as 2,2’,-thiobis-ethanol, on wipes with 3,3’,-thiodipropanol (TDP) as the surrogate. This method is based upon solvent extraction of wipes by either sonication or a pressurized fluid extraction (PFE) technique as an alternative option. The extract is filtered, concentrated and analyzed by liquid chromatography/tandem mass spectrometry (LC/MS/MS). TDG is qualitatively and quantitatively determined.