This document provides guidance for the selection, use and interpretation of results of chemical
indicators used in process definition, validation and routine monitoring and overall control of
sterilization processes. AAMI/ISO 15882:2008 applies to indicators that show exposure to
sterilization processes by means of physical and/or chemical change of substances, and which
are used to monitor one or more of the variables required for a sterilization process. These
chemical indicators are not dependent for their action on the presence or absence of a living
organism.