This document describes procedures for predicting uncertainties in the detection of leaks in pipelines using computational methods based upon physical hydraulic state measurements. This class of pipeline leak detection methods is commonly called computational pipeline monitoring (CPM). Generally, CPM methods take physical measurements from a pipeline as an input, and calculate a metric that is used to assess whether a leak is likely to have occurred. The uncertainty in the CPM method is a fundamentally statistical measure of how likely an alarm is to be valid, equivalently, how often an alarm may be due to routine operational conditions or lie within the realm of known input uncertainty.